Personal page of Vicenta Llorente
93 556 5888
Scientist of the National Scientific Research Council (CSIC) in cardiovascular disease in the Cardiovascular Research Center of the Hospital de la Santa Creu i Sant Pau. Bachelor in Biology from the Univesidad Autónoma de Barcelona. The Ph.D was performed at the Institut of Biochemistry and Molecular Biology of Medicine Faculty at Bern University.
Dr. Llorente is responsible for the research area related to the role of low density lipoprotein receptor-related protein (LRP1) in the lipid accumulation of the vascular wall and the consequences for cellular functionality. The aims of the group are: I. Characterization of aggregated LDL uptake by vascular cells; II. Study of LRP1 transcriptional regulation by risk atherosclerotic factors in in vitro and in vivo models; III. Study of the mechanisms involved in the prothrombotic transformation of vascular cells.
Nowadays, Dr. Llorente is principal investigator of FIS 051717 project entitled "Molecular mechanisms involved in the regulation of the proatherothrombotic role of the lipoprotein receptor LRP1 in the vascular wall, of the intramural project" Effect of aggregated LDL uptake in sphingolipids metabolism in the vascular wall. Consequences for LRP1 and TF expression , key genes in atherotrombosis", and of the RETICS-Heart Failure RD06/0003/0015 entitled "" Identification of pathological molecular mechanisms involved in congestive heart failure and its contribution to the pathogenesis of thus syndrome".Dr. Llorente is responsible for real time PCR equipments (Abiprism 7000 and Apiprism 7900) of the ICCC
- 2011
Cholesterol-lowering strategies reduce vascular LRP1 overexpression induced by hypercholesterolaemia - 2011
Hypoxia exacerbates Ca(2+)-handling disturbances induced by very low density lipoproteins (VLDL) in neonatal rat cardiomyocytes. - 2011
Hypoxia Stimulates Low-Density Lipoprotein Receptor-Related Protein-1 Expression Through Hypoxia-Inducible Factor-{alpha} in Human Vascular Smooth Muscle Cells. - 2011
Modulation of human monocyte CD36 by type 2 diabetes mellitus and other atherosclerotic risk factors. - 2010
Low-density lipoproteins induce heat shock protein 27 dephosphorylation, oligomerization, and subcellular relocalization in human vascular smooth muscle cells.
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Efecto de la captación de LDL agregada en el metabolismo de esfingolípidos en células vasculares. Consecuencias en las vías de regulación de la expresión LRP1 y factor tisular, claves en aterotrombosis.
Molecular pathology of atherosclerosis illness -
Efecto de la isquemia en la expresión y función del receptor LRP1 en pared vascular y miocardio
Molecular pathology of atherosclerosis illness -
Efecto de la LDL modificada en la expresión de adipofilina en macrófagos y células musculares lisas de la pared vascular. Implicaciones para el desarrollo de arteriosclerosis asociada al sindrome metábolico.
Diagnostic and prognostic markers of cardiovascular disease -
Intracellular signal pathways involved in modulation of low density lipoprotein receptor-related protein (LRP1) expression by hypercholesterolemia and hypertension.
Molecular pathology of atherosclerosis illness -
Mecanismos moleculares de regulación de la función proaterotrombótica del receptor lipoproteico LRP1 en la pared vascular
Molecular pathology of the arterial thrombosis -
Redinscor
Other research areas
Catalan Institute of Cardiovascular Sciences
Hospital de la Santa Creu i Sant Pau, Pavelló del Convent
Sant Antoni Maria Claret, 167 08025 Barcelona
Spain
T: +34 - 93 556 5900 F: +34 - 93 556 5559